Cover Picture: Eur. J. Immunol. 8/10

J Immunol

Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of RA in Th17/regulatory T cell generation in vivo, we generated vitamin A-deficient (VAD) mice by c...

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Mucosal Immunol

Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower freque...

Cover Picture Story: Experiments with Modular State Spaces

The main analysis techniques for critical systems use state space exploration. However, one is often quickly limited by the so-called state space explosion problem, even if the systems models are relatively small. Several methods have been proposed to tackle this problem in order to get a manageable state space. One of these takes advantage of the modular structure of the model in order to buil...

Jcb_200810084 797..810

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 5 797–810 www.jcb.org/cgi/doi/10.1083/jcb.200810084 JCB 797 Correspondence to Roger Reddel: [email protected] Z.-H. Zhong’s present address is Promega, Alexandria 2015, New South Wales, Australia. C.D. Toouli’s present address is Bio-Link Australia Pty Ltd, Locomotive Workshop, Eveleigh 2015, New South Wales, Australia. A...